The science behind our ingredients

The ingredients that make up our formulation have been carefully selected based on rigorous studies, efficacy and uncompromising quality.

Please note: All statements made on this website are paraphrased from evidence reported in studies below.

Citicoline

Citicoline, a well-regarded nootropic, stands as a prime example of the impact of scientific research on cognitive function and mental clarity. This unique ingredient, supported by scientific studies and human trials, plays a role in improving brain health. It accomplishes this by aiding in the production of acetylcholine, a neurotransmitter essential for efficient neural communication, and by enhancing cerebral energy metabolism.

Learn more about the research backing this ingredient below.
Research study 1 +

A 28-day study found
that 250 mg and 500 mg of Cognizin® citicoline daily improved attention and
motor speed in healthy adolescent males. These results suggest Cognizin® can
help support focus and cognitive performance in young individuals.

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Research study 2 +

A 12-week study found
that 500 mg of Cognizin® citicoline daily improved episodic memory and overall
memory performance in healthy adults aged 50-85 with age-related memory issues.
These results suggest Cognizin® can help support memory function as we age.

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Research study 3 +

This 28-day study
showed that 250 mg and 500 mg of Cognizin® citicoline daily improved attention
and cognitive performance in healthy adult women. These findings suggest
Cognizin® can help enhance focus and mental clarity.

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Research study 4 +

A study found that
Cognizin® citicoline increased brain energy (ATP) by 14% and sped up brain
membrane formation by 26% in healthy adults. This suggests it can help support
mental energy and overall brain function.

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Research study 5 +

Chronic
supplementation with Cognizin® citicoline increased phosphodiesters in the
brains of healthy older adults, which are essential for maintaining and
repairing cell membranes. It suggests that Cognizin® can help support brain
health and cognitive function as we age.

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Research study 6 +

Cognizin® citicoline
increased brain choline levels in both younger and older adults, but the
effects were more pronounced in older individuals. This suggests that
citicoline may help support brain function and cognitive health, particularly
as people age.

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Bacopa Monnieri

Research suggests that this key plant whose chemical constituents contain bacosides, supports mood, motivation, and working memory. Enhancing mental clarity and cognitive processing.*

Learn more about the research backing this ingredient below.
Research study 1 +

The study on Bacopa
Monnieri showed that it may improve memory and cognitive function, particularly
in individuals with memory impairments. The research indicated that Bacopa
Monnieri helped enhance attention, learning, and memory retention, especially over
the long term. These benefits make it a promising natural ingredient for
supporting brain health.

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Research study 2 +

This meta-analysis
suggests that Bacopa Monnieri has the potential to improve congition,
particularly speed of attention.

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Rhodiola Rosea

An adaptogenic herb that supports mental endurance and combats fatigue, promoting sustained energy, and alertness.*

Learn more about the research backing this ingredient below.
Research study 1 +

This study investigated the effects of low-dose Rhodiola Rosea extract on fatigue in 56
healthy physicians aged 20-35 during night shifts. The doctors were tested on mental fatigue and cognitive functions such as associative thinking, short-term memory, concentration, calculation, and speed of audio-visual perception. The results showed a statistically significant improvement in all five tests for those taking Rhodiola Rosea, indicating that it helps reduce stress-induced
fatigue and improves cognitive performance during night shifts.

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Research study 2 +

This study tested the effect of a single dose of Rhodiola Rosea extract on mental performance and fatigue in 161 cadets aged 19-21. The results showed a significant improvement in mental performance and a reduction in fatigue.

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L-Theanine (Camellia Sinensis)

An amino acid that has been shown in EEG studies to increase alpha-wave activity in the brain, promoting a calm yet focused mental state that may enhance creativity, focus, and attention.*

Learn more about the research backing this ingredient below.
Research study 1 +

This study found that L-theanine, an amino acid found in tea, can increase alpha brain wave activity, which is associated with relaxation and mental alertness, without causing drowsiness. At a dose of 50mg, which is higher than what is typically found in a cup of tea, L-theanine significantly enhanced alpha brain wave activity in
participants.

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Research study 2 +

In this study, healthy adults who took L-theanine for 4 weeks experienced improved cognitive function, verbal fluency, executive function, reduced stress-related symptoms,
and better sleep quality compared to a placebo.

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Research study 3 +

Adults aged 50-69 who
took a single dose and regular intake of L-theanine showed improvements in
attention, working memory, and executive functions. Theanine helped reduce
reaction time in attention tasks and improved performance in working memory
tasks, suggesting its potential to enhance cognitive function.

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L-Tyrosine

An amino acid that plays a key role in producing neurotransmitters that support focus, mental performance, and resilience to stress

Learn more about the research backing this ingredient below.
Research study 1 +

Cognitive studies found that tyrosine can help counteract declines in working memory and information processing caused by stressors like extreme weather or cognitive
overload. This suggests that tyrosine may help maintain brain function in demanding situations by replenishing catecholamines.

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Research study 2 +

The study suggests that the regular consumption of tyrosine, may help enhance cognitive performance, particularly in working memory, fluid intelligence, and episodic memory. The findings extend previous research on the cognitive benefits of tyrosine supplementation, supporting the idea that habitual dietary intake may
also positively impact brain function.

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Research study 3 +

In a study with 16 healthy young adults, the results showed that tyrosine improved performance on two cognitive tasks, particularly those sensitive to stress.

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Gingko Biloba

Clinical studies suggest that it increases blood flow to the brain, delivering vital oxygen improving information processing speed, recall, and working memory.*

Learn more about the research backing this ingredient below.
Research study 1 +

Studies suggest that Ginkgo Biloba extract can improve cognitive function and memory in conditions such as Alzheimer's disease, age-related dementia, and cerebral insufficiency. It works by enhancing cerebral blood flow, offering antioxidant and anti-inflammatory effects, and providing antiplatelet properties.

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Research study 2 +

Research shows Gingko Biloba extract can help with cerebrovascular insufficiency, memory impairment in the elderly, Alzheimer's disease, resistant depression, and other disorders.

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Lion's Mane

A mushroom that supports overall cognitive health, memory, and focus.*

Learn more about the research backing this ingredient below.
Research study 1 +

Studies suggest it
supports to improve memory, stimulate nerve growth factor (NGF) production, and
support cognitive function by promoting neurogenesis. It has been particularly
noted for its ability to support brain health and potentially reduce symptoms
of mild cognitive impairment or neurodegenerative conditions.

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B-Vitamins Complex

A proprietary blend of B vitamins, chosen for their benefits in brain health, performance, and energy (including B1, B2, B3, B5, B6, B9 and B12).*

Learn more below...
Research study 1 +

Thiamine is crucial for energy production and nerve function. It plays a vital role in brain
health, enhancing cognitive function and memory. Deficiencies in B1 can lead to
brain fog and poor mental clarity. Research shows that thiamine supplementation can improve mental performance, especially in stressful situations.

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Research study 2 +

Riboflavin helps convert food into energy and is essential for the proper function of the brain. Studies suggest that it supports cognitive function and can improve mental
performance by aiding the efficiency of energy production in the brain.

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Research study 3 +

Niacin is important for maintaining healthy brain function by aiding in neurotransmitter
production. It has been shown to improve cognitive abilities, enhance focus, and reduce mental fatigue, especially in older adults, by supporting brain cell energy production.

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Research study 4 +

Vitamin B5 is critical for synthesising coenzyme A, which is involved in energy metabolism. It helps reduce mental fatigue and stress, supporting cognitive performance. B5 has been linked to improved mood and mental clarity, especially during high-stress periods.

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Research study 5 +

Vitamin B6 plays a key role in neurotransmitter synthesis, such as serotonin and dopamine, affecting mood, memory, and focus. Scientific research has shown that B6 supplementation improves cognitive function, reduces anxiety, and enhances brain function under stress.

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Research study 6 +

Folate helps in the
formation of new cells and supports neurotransmitter function. Research
suggests it plays an important role in brain development and cognitive
function, reducing the risk of cognitive decline and enhancing memory.

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Research study 7 +

Vitamin B12 is essential for maintaining nerve health and supporting cognitive functions like memory and focus. Deficiencies in vitamin B12 are linked to cognitive decline,
and studies have shown that B12 supplementation can improve cognitive performance, especially in older adults.

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Vitamin D3

An essential vitamin that supports cognitive performance, mood, and the immune system.*

Learn more about the research backing this ingredient below.
Research study 1 +

Research shows that vitamin D plays a crucial role in brain health, with its active form providing neuroprotective effects such as clearing amyloid plaques linked to Alzheimer’s disease. Studies have found that low vitamin D levels are associated with an
increased risk of cognitive decline, dementia, and stroke. Deficiency can lead to up to four times greater risk of cognitive impairment

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Research study 2 +

Research suggests that vitamin D plays a role in mental health, with deficiency linked to an
increased risk of major depressive disorder (MDD) and anxiety. Clinical studies indicate that vitamin D supplementation can reduce symptoms of depression and anxiety, particularly in individuals diagnosed with MDD.

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